A few gray and white hairs will blend in sufficiently not to be noticeable, but as they become more widespread, there will come a point where a semi-permanent alone will not be enough. The move to 100% permanent color can be delayed by using a semi-permanent as a base color, with permanent highlights. Semi-permanent hair color cannot lighten hair. Hair can only be lightened using chemical lighteners, such as bleach. Bleaching is always permanent because it removes the natural pigment. "Rinses" are a form of temporary hair color, usually applied to hair during a shampoo and washed out again the next time the hair is washed. Two types of pigment give hair its color: eumelanin and pheomelanin. Pheomelanin colors hair red. Eumelanin, which has two subtypes of black or brown, determines the darkness of the hair color. A low concentration of brown eumelanin results in blond hair, whereas a higher concentration of brown eumelanin will color the hair brown. High amounts of black eumelanin result in black hair, while low concentrations give gray hair. All humans have some pheomelanin in their hair. Pheomelanin is more chemically stable than black eumelanin, but less chemically stable than brown eumelanin, so it breaks down more slowly when oxidized. This is why bleach gives darker hair a reddish tinge during the artificial coloring process. As the pheomelanin continues to break down, the hair will gradually become orange, then yellow, and finally white. The genetics of hair colors are not yet firmly established. According to one theory, at least two gene pairs control human hair color.
A one-color permanent dye creates a flat, uniform color across the whole head, which can look unnatural and harsh, especially in a dark shade. To combat this, the modern trend is to use multiple colors - usually one color as a base with added highlights or lowlights in other shades. Semi-permanent color washes out over a period of time – typically four to six weeks, so root regrowth is less noticeable. The final color of each strand is affected by its original color and porosity, so there will be subtle variations in color across the head - more natural and less harsh than a permanent dye. However, this means that gray and white hair will not dye to the same color as the rest of the head (in fact, some white hair will not absorb the color at all).
Permanent hair color gives the most flexibility because it can make hair lighter or darker as well as changing tone and color, but there are negatives. Constant (monthly or six-weekly) maintenance is essential to match new hair growing in to the rest of the hair, and remedy fading.